![]() Both types of MEs contain multiple members that are distributed in different organelles within the cell and perform their respective functions. 1 And they are widely found in nature, including bacteria, archaea, fungi, animals and plants. Depending on the cofactors, plant MEs can be divided into NAD + dependent malic enzymes (NAD-ME EC 1.1.1.38 and EC 1.1.1.39) and NADP + dependent malic enzymes (NADP-ME EC 1.1.1.40). It can combine the coenzyme to catalyze the reversible reaction of malate oxidative decarboxylation, produce pyruvic acid and CO 2, and accompany the production of NAD(P)H. Malic enzyme (ME) is a key enzyme regulating malic acid metabolism. It provides a theoretical basis for the future use of ME gene for molecular resistance breeding. In this review, we discuss the important role of ME in plant development and plant stress response, and prospects for its application. Numerous studies have shown that ME participates in the process of coping with the above environmental factors by increasing water use efficiency, improving photosynthesis of plants, providing reducing power, and so on. ![]() Plants are stressed by various environmental factors such as drought, high salt, and high temperature during plant growth, and the mechanisms of plant response to various environmental stresses are synergistic. It is involved in plant growth, development, and stress response. ME is widely present in plants and mainly discovered in cytoplasmic stroma, mitochondria, chloroplasts. And it is also one of the important enzymes in plant metabolism and is involved in multiple metabolic processes. It is a key enzyme regulating malic acid metabolism and can catalyze the reversible reaction of oxidative decarboxylation of malic acid. Malic enzyme (ME) comprises a family of proteins with multiple isoforms located in different compartments of eukaryotic cells.
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